Hydrolysis of phosphohistidine in water and in prostatic acid phosphatase.
نویسندگان
چکیده
Calculation of the free energy profile for hydrolysis of phosphohistidine using ONIOM methodology indicates a much tighter transition state in the enzyme active site compared to that in explicit water and elucidates the role of active site residues in catalysis.
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ورودعنوان ژورنال:
- Chemical communications
دوره 42 شماره
صفحات -
تاریخ انتشار 2009